Synthesis of spiroisoxazoline[5.3(1)]-chroman-4(1)-one

Authors
Manikandan, S Shanmugasundaram, M Raghunathan, R Malar, EJP
Citation
S. Manikandan et al., Synthesis of spiroisoxazoline[5.3(1)]-chroman-4(1)-one, HETEROCYCLE, 53(3), 2000, pp. 579
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
3
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000301)53:3<579:SOS>2.0.ZU;2-L
Abstract
Synthesis of a series of spiro[3,4-diaryl-4,5-dihydroisoxazole-5,3(1)-chrom an-4(1)-one] has been accomplished in good yields by regioselective 1,3-dip olar cycloaddition of nitrile oxide to 3-arylidene-4-chromanone. X-Ray crys tal structure analysis of one of the products confirms the structure and th e regiochemistry of cycloaddition.