Synthesis of some new spiropyrazolo[4 ',5 ': 5,6]-pyrano[2,3-d]pyrimidines

Authors
Al-Thebeiti, MS
Citation
Ms. Al-thebeiti, Synthesis of some new spiropyrazolo[4 ',5 ': 5,6]-pyrano[2,3-d]pyrimidines, HETEROCYCLE, 53(3), 2000, pp. 621
Citations number
30
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
3
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000301)53:3<621:SOSNS'>2.0.ZU;2-U
Abstract
3-Methylpyrazolin-5-ones (1a,b) were reacted with cycloalkanones (2a-d) in the presence of fused sodium acetate to give the corresponding cycloalkylid ene derivatives (3a-h). Reaction of compounds (3a-h) with malononitrile gav e the pyrano derivatives (4a-h), which were cyclized to pyranopyrimidines w ith acetic anhydride/pyridine, formamide and formamide/formic acid.