Gaulthrins C and D, two new lignans from the roots of Gaultheria Yunnanensis

Two new lignans, designated as gaultherins C (1) and D (2), were isolated f rom roots of Gaultheria yunnanensis. Their structures were determined as 1, 3, 3a alpha, 4 alpha, 9, 9 alpha beta-hexahydro-4-( 4-hydroxy-3,5-dimethox yphyenyl)-5,7-dimethoxy-naphtho[2,3-c]furan-6-ol (1) and 1,3,3a alpha,4 alp ha, 9,9 alpha beta-hexahydro-4-(4-hydroxy-3,5-dimethoxyphyenyl)-7-methoxyn aphtho[2,3-c]furan-6-ol (2) based on the physico-chemical properties and th e extensive NMR (DEPT, DQF-COSY, HETCOR, phase-sensitive NOESY, and HMBC ex periments) studies.