The analysis of basic and acidic compounds using non-aqueous CE and non-aqueous CE-MS

It has been shown that non-aqueous capillary electrophoresis (NACE) can pro vide improved separations in comparison to those obtained using conventiona l CE under aqueous conditions [1] (ACE). Previous work carried out in our l aboratories involving initial investigations into the technique have been r eported [2]. Based on the findings of that work it was possible to separate a variety of basic pharmaceuticals from selected impurities and to obtain the successful separation of some hydrophobic sulphonic acids. The successf ul coupling of NACE to mass spectrometry (NACE-MS) has also been demonstrat ed. (C) 2000 Elsevier Science B.V. All rights reserved.