Treatment of severe atopic dermatitis by topical immune modulation using dinitrochlorobenzene

We present the results of a small uncontrolled pilot trial which suggest th at contact sensitization to dinitrochlorobenzene and repeated weekly applic ations significantly improve the clinical status of severe atopic dermatiti s in adults. Although no changes were noted in circulating levels of either lymphocyte subset populations or the serum cytokines assayed in this trial , our observations may be due to topical immune modulation by dinitrochloro benzene. Larger controlled studies of dinitrochlorobenzene treatment in ato pic dermatitis are warranted.