The reaction of 3-nitropyridine with an aqueous solution of sodium sulfite
gave the disodium salt of 5-(N-sulfohydroxyamino)pyridine-2-sulfonic acid (
2) which on treatment with an acidic ion exchange resin gave 5-hydroxyamino
pyridine-2-sulfonic acid (3). The yield of 3 from 3-nitropyridine was 63%.
The structures of the products were verified by X-ray analysis.