Red cells I: inherited anaemias

Examination of the genetic mechanisms underlying the thalassaemias has led to a clearer understanding of the control of eukaryotic genes in general. Inherited disorders of haemoglobin synthesis are an important cause worldwi de of morbidity and mortality, and place a large burden on patients, famili es, and ultimately communities. The haemoglobin disorders can be controlled, by counselling and prenatal di agnosis. Treatment is usually symptomatic, though bone-marrow transplantation for be ta-thalassaemia may be successful in suitable patients.