The minimally invasive approach to olfactory neuroblastoma: Combined endoscopic and stereotactic treatment

Objectives: To describe a new treatment modality of olfactory neuroblastoma consisting of endoscopic nasal and paranasal sinus surgery and stereotacti c radiosurgery, Study Design: Retrospective review of three patients suffer ing from olfactory neuroblastoma. Methods: Review of the charts, the comput ed tomography, and magnetic resonance imaging scans, the operation reports, radiosurgical data, and follow-up. Results: AU three patients remained fre e of disease with excellent quality of life in respective follow-up periods of 71, 50, and 39 months. Conclusion: The combination of two minimally inv asive therapies, endoscopic sinus surgery and stereotactic radiosurgery, pr ovide a reliable new approach to the treatment of a series of olfactory neu roblastomas that offers excellent quality of life, less injury to the patie nt, fewer side-effects, and fewer long-term effects than other treatment st rategies.