Bioaffinity NMR is based on the observation of transferred NOE (trNOE) effe
cts which stem from bioactive components in a mixture containing a library
of small compounds and a protein target. Zero-quantum coherence signals can
interfere with the trNOE cross peaks and, in the worst case, prevent the d
etection of a bioactive compound in a library. The dephasing of these zero-
quantum coherence signals during the experiment significantly improves the
bioaffinity NMR spectra obtained and greatly reduces the risk of misinterpr
etations. Copyright (C) 2000 John Wiley & Sons, Ltd.