Physostigmine in the treatment of gamma-hydroxybutyric acid overdose

Authors
Yates, SW Viera, AJ
Citation
Sw. Yates et Aj. Viera, Physostigmine in the treatment of gamma-hydroxybutyric acid overdose, MAYO CLIN P, 75(4), 2000, pp. 401-402
Citations number
8
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
MAYO CLINIC PROCEEDINGS
ISSN journal
00256196 → ACNP
Volume
75
Issue
4
Year of publication
2000
Pages
401 - 402
Database
ISI
SICI code
0025-6196(200004)75:4<401:PITTOG>2.0.ZU;2-D
Abstract
The widespread abuse of the recreational drug gamma-hydroxybutyric acid has resulted in several reports of overdose leading to coma. The use of a shor t-acting anticholinesterase agent such as physostigmine as a potential reve rsal agent has been proposed previously. We report 2 cases of gamma-hydroxy butyric acid-induced coma that rapidly reversed with intravenous administra tion of physostigmine.