Unexpected isomerization in the series of fluorine-containing 2,3-dihydro-1H-1,4-diazepines with a 2-aminoethyl group at one of the nitrogen atoms

Authors
Sosnovskikh, VY Vorontsov, II Kutsenko, VA Yatluk, YG
Citation
Vy. Sosnovskikh et al., Unexpected isomerization in the series of fluorine-containing 2,3-dihydro-1H-1,4-diazepines with a 2-aminoethyl group at one of the nitrogen atoms, MENDELEEV C, (2), 2000, pp. 56-57
Citations number
6
Categorie Soggetti
Chemistry
Journal title
MENDELEEV COMMUNICATIONS
ISSN journal
09599436 → ACNP
Issue
2
Year of publication
2000
Pages
56 - 57
Database
ISI
SICI code
0959-9436(2000):2<56:UIITSO>2.0.ZU;2-#
Abstract
Under kinetic control conditions, 6-methoxy-2-(1,1,2,2-tetrafluoroethyl)chr omone reacts with diethylenetriamine to form 5-(2-hydroxy-5-methoxyphenyl)- 7-(1,1,2,2-tetrafluoroethyl)-1,4,8-triazabicyclo[5.3.0]dec-4-ene, and the l atter undergoes isomerization to the title compound, which is more thermody namically stable.