Design and synthesis of a conformationally rigid mimic of the dihydropyrimidine calcium channel modulator SQ 32,926

Authors
Jauk, B Pernat, T Kappe, CO
Citation
B. Jauk et al., Design and synthesis of a conformationally rigid mimic of the dihydropyrimidine calcium channel modulator SQ 32,926, MOLECULES, 5(3), 2000, pp. 227-239
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MOLECULES
ISSN journal
14203049 → ACNP
Volume
5
Issue
3
Year of publication
2000
Pages
227 - 239
Database
ISI
SICI code
1420-3049(200003)5:3<227:DASOAC>2.0.ZU;2-L
Abstract
A conformationally rigid polyheterocycle (3) which mimics the putative rece ptor-bound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyc locondensation reaction.