Ga. Rodrigo et al., Synthesis and physicochemical study of a quinoxaline derivative with potencial antineoplasic or anti-HIV activity, MOLECULES, 5(3), 2000, pp. 358-359
Kinetics of the synthesis of 3-[3-quinoxaline(1H)-one]propionic acid (I) we
re performed. This compound was achieved from reaction between o-phenylened
iamine and alpha-ketoglutaric acid under different experimental conditions,
and it was sent to the National Cancer Institute (USA) for its pharmacolog
ical evaluation.