Recognizing misfolded proteins in the endoplasmic reticulum

Authors
Matouschek, A
Citation
A. Matouschek, Recognizing misfolded proteins in the endoplasmic reticulum, NAT ST BIOL, 7(4), 2000, pp. 265-266
Citations number
32
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
7
Issue
4
Year of publication
2000
Pages
265 - 266
Database
ISI
SICI code
1072-8368(200004)7:4<265:RMPITE>2.0.ZU;2-1
Abstract
The mechanism by which cells recognize misfolded proteins in the endoplasmi c reticulum has been defined at the cell biological level. The enzyme UDP-g lucose:glycoprotein glucosyltransferase identifies and specifically glucosy lates misfolded domains within a multi-domain protein.