The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats

Authors
Li, ZQ Yamamoto, Y Morimoto, T Ono, J Okada, S Yamatodani, A
Citation
Zq. Li et al., The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats, NEUROSCI L, 282(1-2), 2000, pp. 117-119
Citations number
15
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
282
Issue
1-2
Year of publication
2000
Pages
117 - 119
Database
ISI
SICI code
0304-3940(20000317)282:1-2<117:TEOPOT>2.0.ZU;2-K
Abstract
We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glut amate level was observed in the kindled rats, in contrast, a slight and del ayed increase was observed in the non-kindled rats when the same grade seiz ure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.