Sv. Moran et al., Comparison of two doses of aprotinin in patients receiving aspirin before coronary bypass surgery, PERFUSION-U, 15(2), 2000, pp. 105-110
This study was designed to evaluate efficacy and tolerability of two differ
ent doses of aprotinin in patients receiving aspirin before undergoing coro
nary artery bypass grafting. Forty-two patients were randomized to receive
either placebo (group I), or aprotinin in doses of 4 000 000 KIU (group II)
or 6 000 000 KIU (group III). Drug efficacy was determined by measuring po
stoperative blood loss and transfusion of blood products. Both doses were e
ffective in reducing blood loss and transfusion requirements. Blood loss th
rough thoracotomy drainage was 450 +/- 224, 182 +/- 144, 142 +/- 98 mi, res
pectively, for control and treatment groups II and III (p = 0.0001). The nu
mbers of patients with blood transfusions were seven (50%), two (17%) and t
wo (17%) for group I and treatment groups II and ill, respectively (p = 0.1
0). Tolerability was excellent and complications few and reversible.
In conclusion, high and medium doses of aprotinin were well tolerated and r
educed bleeding and transfusion requirements in patients submitted to coron
ary bypass surgery under the effects of aspirin.