Nuclear chaperones

We discuss nuclear chaperones that bind correctly folded protein subunits a nd mediate molecular interactions, particularly between proteins and nuclei c acids. The clarge of these chaperones helps to prevent non-specific elect rostatic interactions between the components. Thus, an ordered assembly of macromolecular complexes is mediated most notably in the formation and main tenance of chromatin, though similar principles ere likely to apply in ribo nucleoprotein assembly. Here, we discuss roles for nuclear chaperones ones in mediating nucleosome assembly and remodelling during DNA replication and transcription, and upon fertilisation.