The second-derivative spectrophotometric assay of a multicomponent analgetic mixture

In this paper the second-derivative spectrophotometric method for the simul taneous determination of some analgetic ingredients was described. Optimal conditions for the quantitative analysis of the three-component analgetic m ixture of Dalivon(R) tablets were settled. The second-derivative order of t he spectra in sodium hydroxide with the wavelength modulation was used. For the determination of paracetamol the "zero-crossing" technique was applied , but for propyphenazone and caffeine the characteristic peak amplitude had to be corrected. The authors propose this second-derivative spectrophotometry for a rapid, s imple, precise and accurate determination of the Dalivon(R) tablets or a co rresponding multicomponent mixture.