Repeated measures in clinical trials: simple strategies for analysis usingsummary measures

The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures a re considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic. A compromise trend/mean measure, regression through the origin, is proposed as being useful under some circumstances. An analysis using this measure i s illustrated with a suitable example. Copyright (C) 2000 John Wiley & Sons , Ltd.