Retinoblastoma in adults: Report of three cases and review of the literature

Retinoblastoma usually presents in children younger than 5 years. To our kn owledge, 20 cases of retinoblastoma in adults (older than 20 years) have be en reported in the literature. Of 173 patients with histopathologically pro ven retinoblastoma seen in our institute, three were adults. All the patien ts had endophytic rumors with vitreous seeds. Ultrasonography did not revea l calcification in two cases. Immunohistochemistry with neuron-specific eno lase was used to confirm the diagnosis in two cases. All three patients ult imately required enucleation. None of the patients had been referred with a diagnosis of retinoblastoma. The diagnosis of retinoblastoma should be con sidered in cases of whitish mass lesion in the fundus of an adult. (C) 2000 by Elsevier Science Inc. All rights reserved.