The palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with alkyl halides. An entry into 2-substituted 3-alkylindoles

Authors
Arcadi, A Cacchi, S Fabrizi, G Marinelli, F
Citation
A. Arcadi et al., The palladium-catalyzed reaction of o-alkynyltrifluoroacetanilides with alkyl halides. An entry into 2-substituted 3-alkylindoles, SYNLETT, (3), 2000, pp. 394-396
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
3
Year of publication
2000
Pages
394 - 396
Database
ISI
SICI code
0936-5214(200003):3<394:TPROOW>2.0.ZU;2-T
Abstract
Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepare d usually in good yield through the palladium-catalyzed reaction of o-alkyn yltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best res ults are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl )phosphine in THF.