A versatile multi-component one-pot thiazole synthesis

Authors
Heck, S Domling, A
Citation
S. Heck et A. Domling, A versatile multi-component one-pot thiazole synthesis, SYNLETT, (3), 2000, pp. 424-426
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
3
Year of publication
2000
Pages
424 - 426
Database
ISI
SICI code
0936-5214(200003):3<424:AVMOTS>2.0.ZU;2-P
Abstract
A new multi-component reaction (MCR) of oxo components, primary amines, thi ocarboxylic acids and a special isocyanide yielding 2,4-disubstituted thiaz oles is described. This one-pot, one-step reaction is an alternative to cur rent methods of thiazole ring formation and can be applied to combinatorial chemistry as well as in the total synthesis of thiazole containing natural products.