Aj. Sternberg et al., Severe haemolysis after an ABO unmatched kidney transplant - a nonsecretortransplanted from a donor with high anti-A titre, TRANSFUS M, 10(1), 2000, pp. 87-89
A case of severe haemolysis following an ABO unmatched renal transplant is
reported in a group A nonsecretor who received a kidney from a group O livi
ng related donor. Following the haemolytic episode, group A donor units wer
e incompatible and the patient was transfused with group O blood. Serologic
al investigation of the recipient revealed anti-A present in the serum and
on the red cells. Investigation of the donor revealed the presence of high-
titre anti-A. The association of such high-titre donor antibody with haemol
ysis in ABO unmatched grafts has not been reported before. We discuss the r
isk factors for developing haemolysis in an ABO unmatched organ transplant
and explore the possible relevance of such high donor antibody titre to rec
ipients who are nonsecretors.