APOLIPOPROTEIN-E GENE AND SPORADIC FRONTAL-LOBE DEMENTIA

Citation
M. Stevens et al., APOLIPOPROTEIN-E GENE AND SPORADIC FRONTAL-LOBE DEMENTIA, Neurology, 48(6), 1997, pp. 1526-1529
Citations number
31
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00283878
Volume
48
Issue
6
Year of publication
1997
Pages
1526 - 1529
Database
ISI
SICI code
0028-3878(1997)48:6<1526:AGASFD>2.0.ZU;2-6
Abstract
The apolipoprotein E gene has been associated with various types of de mentia. We studied the connection between the APOE gene and the risk a nd onset of disease in 34 patients with clinically diagnosed frontal l obe dementia (FLD) derived from a population-based study in the Nether lands. A significant increased risk of FLD (odds ratio, 4.9; 95% CI, 1 .1-20.1) was found for the apoE4E4 genotype when adjusting for age, se x, and family history of dementia other than FLD. The age at onset of the disease decreased as the number of APOE4 alleles increased. Our p opulation based study suggests that persons who are homozygous for the APOE4 allele are at increased risk for developing FLD.