Detection of low- and high-frequency rhythms in the variability of skin sympathetic nerve activity

Spectral analysis of skin blood flow has demonstrated low-frequency (LF, 0. 03-0.15 Hz) and high-frequency (HF, 0.15-0.40 Hz) oscillations, similar to oscillations in R-R interval, systolic pressure, and muscle sympathetic ner ve activity (MSNA). It is not known whether the oscillatory profile of skin blood flow is secondary to oscillations in arterial pressure or to oscilla tions in skin sympathetic nerve activity (SSNA). MSNA and SSNA differ marke dly with regard to control mechanisms and morphology. MSNA contains vasocon strictor fibers directed to muscle vasculature, closely regulated by barore ceptors. SSNA contains both vasomotor and sudomotor fibers, differentially responding to arousals and thermal stimuli. Nevertheless, MSNA and SSNA sha re certain common characteristics. We tested the hypothesis that LF and HF oscillatory components are evident in SSNA, similar to the oscillatory comp onents present in MSNA. We studied 18 healthy normal subjects and obtained sequential measurements of MSNA and SSNA from the peroneal nerve during sup ine rest. Measurements were also obtained of the electrocardiogram, beat-by -beat blood pressure (Finapres), and respiration. Spectral analysis showed LF and I-IF oscillations in MSNA, coherent with similar oscillations in bot h R-R interval and systolic pressure. The HF oscillation of MSNA was cohere nt with respiration. Similarly, LF and HF spectral components were evident in SSNA variability, coherent with corresponding variability components of R-R interval and systolic pressure. HF oscillations of SSNA were coherent w ith respiration. Thus our data suggest that these oscillations may be funda mental characteristics shared by MSNA and SSNA, possibly reflecting common central mechanisms regulating sympathetic outflows subserving different reg ions and functions.