Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis

Citation
Sj. Shankland et G. Wolf, Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis, AM J P-REN, 278(4), 2000, pp. F515-F529
Citations number
152
Categorie Soggetti
da verificare
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
ISSN journal
03636127 → ACNP
Volume
278
Issue
4
Year of publication
2000
Pages
F515 - F529
Database
ISI
SICI code
0363-6127(200004)278:4<F515:CCRPIR>2.0.ZU;2-5
Abstract
The response to glomerular and tubulointerstitial cell injury in most forms of renal disease includes changes in cell number (proliferation and apopto sis) and cell size (hyerptrophy). These events typically precede and may be reponsible for the accumulation of extracellular matrix proteins that lead s to a decrease in renal function. There is increasing evidence showing tha t positive (cyclins and cyclin-dependent kinases) and negative (cyclin-depe ndent kinase inhibitors) cell cycle regulatory proteins have a critical rol e in regulating these fundamental cellular responses to immune and nonimmun e forms of injury. Data now show that altering specific cell cycle proteins affects renal cell proliferation and improves renal function. Equally exci ting is the expanding body of literature showing novel biological roles for cell cycle proteins in the regulation of cell hypertrophy and apoptosis. W ith increasing understanding of the role for cell cyle regulatory proteins in renal disease comes the hope for potential therapeutic inverventions.