The vagus nerve is involved in the anorexigenic effect of simmondsin in the rat

Simmondsin, 2-(cyanomethylene)-3 hydroxy 4,5 dimethoxy cyclohexyl beta-D-gl ucoside, from jojoba meal reduces food intake in rats. We investigated the mechanism of action simmondsin, by studying the effects of fasting or of va gotomy on the food intake reduction. The food intake reduction was signific antly less in fasted rats than in nonfasted rats. The reduction of food int ake was also significantly diminished after vagotomy. The results of the pr esent experiments suggest that simmondsin reduces intake of food in rats th rough the augmentation of satiety, in part vagally mediated. (C) 2000 Acade mic Press.