LARGE B-CELL LYMPHOMA OF THE UTERINE CORPUS - CASE-REPORT WITH IMMUNOHISTOCHEMICAL AND MOLECULAR STUDY

Primary lymphoma of the uterine corpus (PLUG) is an extremely rare neo plasm. We report a case of PLUG in a 78-year-old woman with vaginal bl eeding without hepatosplenomegaly, adenopathies, or bone marrow infilt ration, classified as stage I. A diagnosis of diffuse large B-cell lym phoma was made in endometrial curettage tissue. Immunohistochemical st udy showed tumoral cells of B-cell nature. Two different polymerase ch ain reaction (PCR) techniques showed imnunoglobulin heavy chain gene r earrangement and we could not demonstrate, with PCR technique, either Epstein-Barr virus or papilloma virus infection. Total hysterectomy wi th bilateral salpingo-oophorectomy was carried out and adjuvant chemot herapy was given. She was alive and free of disease after a follow-up period of 7 years, and the patient has been in perfect health. (C) 199 7 Academic Press.