Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19: Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities
T. Erker et al., Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. Part 19: Thieno[2,3-b][1,4]thiazines with calcium antagonistic and potassium opening activities, ARCH PHARM, 333(2-3), 2000, pp. 58-62
In this study novel substituted 6-benzyl-thieno[2,3-b] [1,4]thiazines with
an urea moiety were synthesized. Structural modifications of the amino side
chain were carried out with the aim of finding tissue specific compounds.
The effects on papillary muscles, right atria, aortic strips, and terminal
ilea were investigated. Compounds 10c and 10d showed the most potent negati
ve inotropic effect. The calcium antagonism of all derivatives occurred in
a non-competitive manner, which may indicate that they also have potassium
channel opening activities.