Impact of laparoscopic staging in the treatment of pancreatic cancer

Hypothesis: Staging laparoscopy in patients with pancreatic cancer identifi es unsuspected metastases, allows treatment selection, and helps predict su rvival. Design: Inception cohort. Setting: Tertiary referral center. Patients: A total of 125 consecutive patients with radiographic stage II to III pancreatic ductal adenocarcinoma who underwent staging laparoscopy wit h peritoneal cytologic examination between July 1994 and November 1998. Sev enty-eight proximal tumors and 47 distal rumors were localized. Interventions: Based on the findings of spiral computed tomography (CT) and laparoscopy, patients were stratified into 3 groups. Group 1 patients had unsuspected metastases found at laparoscopy and were palliated without furt her operation. Group 2 patients had no demonstrable metastases, but CT indi cated unresectability due to vessel invasion. This group underwent external beam radiation with fluorouracil chemotherapy followed in selected cases b y intraoperative radiation. Patients in group 3 had no metastases or defini tive vessel invasion and were resection candidates. Results: Staging laparoscopy revealed unsuspected metastases in 39 patients (31.2%), with 9 having positive cytologic test results as the only evidenc e of metastatic disease (group 1). Fifty-five patients (44.0%) had localize d but unresectable carcinoma (group 2), of whom 2 (3.6%) did not tolerate t reatment, 20 (36.4%) developed metastatic disease during treatment, and 21 (38.2%) received intraoperative radiation. Of 31 patients with potentially resectable tumors (group 3), resection for cure was performed in 23 (resect ability rate, 74.2%). Median survival was 7.5 months for patients with meta static disease, 10.5 months for those receiving chemoradiation, and 14.5 mo nths for those who underwent tumor resection (P = .01 for group 2 vs group 1; P < .001 for group 3 vs group 1). Conclusions: Staging laparoscopy, combined with spiral CT, allowed stratifi cation of patients into 3 treatment groups that correlated with treatment o pportunity and subsequent survival. Among the 125 patients, laparoscopy obv iated 39 unnecessary operations and irradiation in patients with metastatic disease not detectable by CT. Laparoscopic staging can help focus aggressi ve treatment on patients with pancreatic cancer who might benefit.