Multicentric reticulohistiocytosis - Case report with immunohistochemical analysis and literature review

This report describes the case of a patient with multicentric reticulohisti ocytosis. Immunohistochemical analysis revealed prominent markers of monocy te/macrophage origin, as well as the presence of tumor necrosis factor alph a, interleukin-1 beta (IL-1 beta), and IL-12; the occurrence of the latter in this disease has not previously been reported. Clinical, laboratory, rad iographic, and histologic findings in multicentric reticulohistiocytosis ar e reviewed. In addition, all published cases of multicentric reticulohistio cytosis which included reports of cytokine and immunohistochemical analysis are reviewed, and evidence fur a monocyte/macrophage origin and role in di sease pathogenesis is provided.