Synthesis of some new thienyl and 1,3-thiazolyl-aminoketones with anti-inflammatory activity

Authors
Geronikaki, AA Hadjipavlou-Litina, DJ Tzaki, M
Citation
Aa. Geronikaki et al., Synthesis of some new thienyl and 1,3-thiazolyl-aminoketones with anti-inflammatory activity, ARZNEI-FOR, 50(3), 2000, pp. E266-E271
Citations number
20
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
50
Issue
3
Year of publication
2000
Pages
E266 - E271
Database
ISI
SICI code
0004-4172(200003)50:3<E266:SOSNTA>2.0.ZU;2-P
Abstract
Eight thienyl and 1,3-thiazolyl-aminoketones were synthesised and tested as anti-inflammatory agents. pKa and log P were theoretically calculated. The compounds were tested for antioxidant activity, as hydroxyl radical scaven gers, as superoxide anion scavengers and for their ability to interact with 1,1-diphenyl-2-picryl hydrazyl stable free radical (DPPH). The effects of the synthesised compounds on inflammation were studied using the carrageena n induced mice paw oedema model. Both anti-inflammatory and antioxidant act ivities depended on some structural characteristics of the synthesised comp ounds.