We present the first results of a long-term optical spectroscopic monitorin
g program of a sample of 14 luminous (L-Bol similar to 10(4.5)-10(4.6) ergs
s(-1)) low-redshift (z = 0.14-0.59) quasars. Our spectra have been taken a
nnually over a period of 5 yr and for four objects have been supplemented b
y digital spectra obtained approximately 20 years earlier. For these four o
bjects, we find relatively little change in both the shapes and fluxes of t
he broad lines from the first observations to the present. However, in one
quasar, B2 1721 + 34, the emission in the core of the H alpha profile has d
ecreased while that in the profile wings has increased, suggesting that mat
erial has moved from the outer intermediate-line region to the inner very b
road line region (VBLR). Our 5 year monitoring campaign reveals variability
in the core, but not the wings, of the H beta profile of several objects i
n response to variations in the continuum. In a few objects, notably PKS 14
51-37, we observe year-to-year variability in the strength of the He II lam
bda 4686 line that also appears to be a response to variability in the ioni
zing continuum. The lack of significant long-term variability in the wings
of the Balmer lines supports models in which the VBLR takes the form of a r
elativistic accretion disk, as opposed to an episodic flow to or from the c
entral engine. In the latter case, current constraints on the gas crossing
time of the VBLR indicate that variability would occur on a timescale of mo
nths, which we do not observe. The lack of response of the wings of H beta
to continuum variability provides additional evidence that the VBLR is full
y ionized in hydrogen.