Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII)

Exaggerated postprandial lipemia is believed to be atherogenic and to influ ence risk of thrombosis. The postprandial effects on plasma triacylglycerol concentration, factor VII coagulant activity (FVIIc) and activated FVII co ncentration (FVIIa) of five high fat meals (5.2 MJ, 90 g fat) enriched with medium triacylglycerols (MCT, 8:0 + 10:0), palmitate(16:0), stearate (18:0 ), elaidate(18:1 trans) and oleate(18:1 cis) were compared with those follo wing a low fat meal (5.2 MJ,10 g fat) in 16 healthy subjects using a random ized crossover design. Postprandial lipemia measured as the area under the curve (AUC arbitrary units) for plasma triacylglycerol concentration (mean +/- SE) was greater following the oleate (5.8 +/- 1.05), elaidate (4.3 +/- 0.79) and palmitate (4.1 +/- 0.64) meals compared with stearate (2.0 +/- 0. 45) and MCT (1.1 +/- 0.47) meals. Fatty acid analyses of the chylomicron li pids suggested that approximately one fifth of the dietary stearate was not absorbed. FVIIc increased following the oleate, elaidate and palmitate mea ls and fell following the low fat meal; the increase in FVIIc was correlate d with the AUC for plasma TAG (r = 0.34; P = 0.001). FVIIa concentration in creased following all high fat meals but not following the low fat meal. Th e increase in FVII, at 7 h was greater after the oleate meal than after the stearate and MCT meals. These results do not support the hypothesis that d ietary stearate and elaidate are responsible for the postprandial increases in FVII associated with high fat intakes. (C) 2000 Elsevier Science Irelan d Ltd. All rights reserved.