Tv. Abramova et al., Synthesis and properties of photolabile (caged) phosphotriester derivatives of dinucleoside phosphates, BIOORG KHIM, 26(3), 2000, pp. 197-205
Dinucleoside phosphates that harbor phosphate groups transiently blocked (c
aged) by o-nitrobenzyl or o-nitroveratryl residues were synthesized. It was
shown that the conditions of the UV-induced deprotection largely depend on
the nature of the protective group. The phosphotriesters obtained were res
istant toward snake venom phosphodiesterase and nucleases of the cellular e
xtract. The synthesis of the dinucleoside phosphates containing a photolabi
le group preceded the incorporation of the modified blocks into extended ol
igonucleotides by the phosphoramidite method.