The phospholipase-induced degradation of phosphatidylnucleosides

Authors
Novozhilova, TI Malekin, SI Kozhukhov, VI Kruglyak, YL Kurochkin, VK
Citation
Ti. Novozhilova et al., The phospholipase-induced degradation of phosphatidylnucleosides, BIOORG KHIM, 26(3), 2000, pp. 238-240
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANICHESKAYA KHIMIYA
ISSN journal
01323423 → ACNP
Volume
26
Issue
3
Year of publication
2000
Pages
238 - 240
Database
ISI
SICI code
0132-3423(200003)26:3<238:TPDOP>2.0.ZU;2-Z
Abstract
Hydrolysis of phosphatidylnucleosides, 5'-(rac-1-hexadecyl-2-palmitoyl-sn-g lycero-3-phosphoryl)-3'-azido-3'-deoxythymidine and -2',3'-didehydro-3'-deo xythymidine, effected by phospholipases (PL) A(2), C, and D was studied to reveal the metabolism of these derivatives. It was shown that PLA(2) deacet ylates the glycerol residue at position 2. PLC is inactive, anti PLD hydrol yzes the phosphatidylnucleosides to give free nucleosides.