D. Yesilbursa et al., Effects of fosinopril treatment on blood pressure during physical and mental stress test in essential hypertension, BLOOD PRESS, 8(5-6), 1999, pp. 269-272
In this study the effects of once daily administration of 10 mg fosinopril
on blood pressure response to mental and physical stress were evaluated in
mild to moderate essential hypertension. A total of 25 patients (14 women,
9 men) with mild to moderate essential hypertension were enrolled in this s
tudy. Before the treatment and after 10 mg/day fosinopril treatment for 2 m
onths, systolic and diastolic blood pressure and heart rate were recorded a
t rest and while performing a mental arithmetic test. In addition, exercise
stress testing with Bruce protocol were performed before and after the tre
atment and systolic and diastolic blood pressure and heart rate were record
ed at rest and during peak exercise. Statistical analysis were done by usin
g the paired t-test. During the mental arithmetic test, systolic and diasto
lic blood pressure were significantly reduced (p < 0.005 and p < 0.001, res
pectively) after 2 months fosinopril treatment. Systolic and diastolic bloo
d pressure were also significantly reduced during the exercise stress test
(p < 0.005 and p < 0.05) after the treatment. Heart rate did not change dur
ing either the mental arithmetic or the exercise test. As a result, once da
ily 10 mg fosinopril may be effective in reducing blood pressure, not only
at rest, but also during stressful situations.