Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment

Authors
Patel, A Harrison, E Durward, A Murdoch, IA
Citation
A. Patel et al., Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment, BR J ANAEST, 84(4), 2000, pp. 505-507
Citations number
11
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF ANAESTHESIA
ISSN journal
00070912 → ACNP
Volume
84
Issue
4
Year of publication
2000
Pages
505 - 507
Database
ISI
SICI code
0007-0912(200004)84:4<505:IRHDIA>2.0.ZU;2-U
Abstract
Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administr ation of rhDNase to a 3-yr-old boy with acute life-threatening asthma in wh om 48 h of aggressive therapy had failed.