A ring-closing metathesis-mediated route to novel enantiopure conformationally restricted cyclic amino acids

Authors
Tjen, KCMF Kinderman, SS Schoemaker, HE Hiemstra, H Rutjes, FPJT
Citation
Kcmf. Tjen et al., A ring-closing metathesis-mediated route to novel enantiopure conformationally restricted cyclic amino acids, CHEM COMMUN, (8), 2000, pp. 699-700
Citations number
20
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
2000
Pages
699 - 700
Database
ISI
SICI code
1359-7345(2000):8<699:ARMRTN>2.0.ZU;2-8
Abstract
A combination of palladium-catalysed N,O-acetal formation, ruthenium-cataly sed ring-closing metathesis and N-sulfonyliminium ion-mediated C-C bond for mation constitutes an efficient and versatile route to a set of enantiomeri cally pure 2,6-disubstituted unsaturated pipecolic acid derivatives.