Bisphosphonate prodrugs: unusual dimerisation of clodronic acid trimethyl ester to a cyclic bis(bisphosphonate)

Authors
Ahlmark, MJ Ahlgren, M Niemi, R Taipale, H Jarvinen, T Vepsalainen, JJ
Citation
Mj. Ahlmark et al., Bisphosphonate prodrugs: unusual dimerisation of clodronic acid trimethyl ester to a cyclic bis(bisphosphonate), CHEM COMMUN, (8), 2000, pp. 711-712
Citations number
10
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
8
Year of publication
2000
Pages
711 - 712
Database
ISI
SICI code
1359-7345(2000):8<711:BPUDOC>2.0.ZU;2-5
Abstract
Cl2C[P(O)(OMe)(2)P(O)(OMe)(O(-)Z(+))] selectively reacts with acetyl chlori de to provide a new enzymatically stable heterocyclic bis(bisphosphonate); the structure is confirmed by X-ray crystallography.