Arthritis following combined vaccine against diphtheria, polyomyelitis, and tetanus toxoid

We describe 2 cases of arthritis following immunization against diphtheria, poliomyelitis and tetanus toroid. One patient developed monoarthritis of t he knee after immunization, that regressed following synovectomy. Five year s later; the arthritis recurred after a booster vaccine injection. One day after immunization, another patient developed arthritis of the ankle that p ersisted for 3 days. It is difficult to know whether there is a coincidenta l or a causal relation between immunization and arthritis. Although our cas es suggest that immunization against diphtheria, poliomyelitis and tetanus toxoid may cause arthritis, additional cases must be reported before studie s aimed at confirming this possibility ave considered.