6-(hydroxyphenyl)imidazo[2,1-b]thiazoles as potential antiinflammatory agents: Effects on human neutrophil functions

Authors
Andreani, A Rambaldi, M Leoni, A Locatelli, A Morigi, R Traniello, S Cariani, A Rizzuti, O Spisani, S
Citation
A. Andreani et al., 6-(hydroxyphenyl)imidazo[2,1-b]thiazoles as potential antiinflammatory agents: Effects on human neutrophil functions, COLL CZECH, 65(2), 2000, pp. 267-279
Citations number
41
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
2
Year of publication
2000
Pages
267 - 279
Database
ISI
SICI code
0010-0765(200002)65:2<267:6APAA>2.0.ZU;2-R
Abstract
Synthesis of 6-(hydroxyphenyl)imidazo [2,1-b]thiazoles related to levamisol e from the corresponding methoxy derivatives is reported. These compounds w ere tested on in vitro neutrophil activation, namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggere d by agonists. These functions were evaluated after cell pulse with differe nt concentrations of the drugs. Several derivatives showed significant inhi bitory effects, in some cases more potent than the parent compound.