Termination of pregnancies of < 6 weeks gestation with a single dose of 800 mu g of vaginal misoprostol

This study evaluated the effectiveness of a single dose of the abortifacien t effect of vaginal misoprostol followed by prolonged observation. Women wi th less than or equal to 42 days of amenorrhea, pregnancy confirmed by ultr asound and approved request for termination received 800 mu g of vaginal mi soprostol once and were observed for 1 week. The gestational sac was measur ed before misoprostol administration, and 24 h and 7 days afterward. Women reported bleeding, expulsion of sac, and other complaints. After 1 week, th ose who had not aborted received a second dose of 800 mu g. Those who had n ot aborted by 24 h later were treated by Vacuum aspiration of the endometri al cavity. Twenty-four hours after treatment, 71.8% had aborted, and 87.1% aborted 3 days after treatment. After the second dose, 7 days later, the cu mulative abortion rate leached 92.1%. None of the subjects who aborted requ ired curettage or vacuum aspiration. The main complaints were pain (84.5%), nausea (21.4%), and headache (17.5%). No clinical differences between resp onders and nonresponders was found. Vaginal misoprostol, 800 mu g, is effec tive in inducing early termination of pregnancy and there is no need for an additional dose within 72 h after the first administration of misoprostol. CONTRACEPTION 2000;61:47-50 (C) 2000 Elsevier Science Inc. All rights rese rved.