Foreign protein production in plant tissue cultures

Authors
Citation
Pm. Doran, Foreign protein production in plant tissue cultures, CURR OPIN B, 11(2), 2000, pp. 199-204
Citations number
52
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN BIOTECHNOLOGY
ISSN journal
09581669 → ACNP
Volume
11
Issue
2
Year of publication
2000
Pages
199 - 204
Database
ISI
SICI code
0958-1669(200004)11:2<199:FPPIPT>2.0.ZU;2-5
Abstract
Foreign proteins synthesised by plants are now in the marketplace, and clin ical trials for plant-derived therapeutic proteins are underway. Economic a nalysis of plant production systems has helped identify the types of protei n that would be most suitable for manufacture using tissue culture methods. The major advantages associated with in vitro plant systems include the ab ility to manipulate environmental conditions for better control over protei n levels and quality, the rapidity of production compared with agriculture, and the use of simpler and cheaper downstream processing schemes for produ ct recovery from the culture medium.