Structure and function of apolipoprotein A-I and high-density lipoprotein

Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major pro tein component of HDL, apo A-I. For the first time, an atomic resolution ma p is available for future studies of the molecular interactions of HDL in s uch biological processes as ABC1-regulated HDL assembly, LCAT activation, r eceptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL re search. Curr Opin Lipidol 11:105-115. (C) 2000 Lippincott Williams & Wilkin s.