Characterization of a new TSPY gene family member in Yq (TSPYq1)

Authors
Ratti, A Stuppia, L Gatta, V Fogh, I Calabrese, G Pizzuti, A Palka, G
Citation
A. Ratti et al., Characterization of a new TSPY gene family member in Yq (TSPYq1), CYTOG C GEN, 88(1-2), 2000, pp. 159-162
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
88
Issue
1-2
Year of publication
2000
Pages
159 - 162
Database
ISI
SICI code
0301-0171(2000)88:1-2<159:COANTG>2.0.ZU;2-R
Abstract
We investigated subinterval 6E on the human Y chromosome, a region frequent ly deleted in infertile males. YAC yOX 17, mapped within subinterval 6E by STS-PCR, was analyzed for the presence of new genes. TSPYq1, a member of th e TSPY multi-copy gene family, was isolated and characterized from a yOX 17 cosmid subclone. PCR and FISH analysis performed on normal subjects and on patients with microdeletions of Yq suggested the presence of multiple copi es of TSPY in Yq. Copyright (C) 2000 S. Karger AG, Basel.