A rare case of spontaneous regression of esophageal leiomyosarcoma is repor
ted. A 63-year-old woman underwent esophagectomy and reconstruction at our
hospital after diagnosis of leiomyosarcoma, Nineteen months after esophagec
tomy, a coin lesion was detected in the right lung and right thoracotomy re
vealed pleural dissemination. The lesion in the right lung was resected and
was confirmed histologically as recurrence of leiomyosarcoma. During furth
er surgery, metastatic Lesions were found in the spleen and pleura, However
, all metastatic lesions were found to decrease without any anti-cancer the
rapy.