Lubricant susceptibility of cellactose and Avicel PH-200: A quantitative relationship

Authors
Flores, LE Arellano, RL Esquivel, JJD
Citation
Le. Flores et al., Lubricant susceptibility of cellactose and Avicel PH-200: A quantitative relationship, DRUG DEV IN, 26(3), 2000, pp. 297-305
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
ISSN journal
03639045 → ACNP
Volume
26
Issue
3
Year of publication
2000
Pages
297 - 305
Database
ISI
SICI code
0363-9045(2000)26:3<297:LSOCAA>2.0.ZU;2-Z
Abstract
The lubricant susceptibility of two direct compression excipients, Avicel P H-200 and Cellactose, was determined using a model mix with metamizol sodiu m (dipyrone) and designed experiments to obtain a quantitative relationship by multiple regression. As a result, a new constant called specific lubric ant sensibility L-s is proposed for the comparison of lubricant susceptibil ity in other drug-excipient systems.