Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery

With pressure on pharmaceutical companies to reduce time-to-market and impr ove the success rate of new drug candidates, higher-throughput pharmacokine tic (HTPK) support has become an integral part of many drug discovery progr ammes. This report details the amalgamation of robotics, new sample prepara tion technologies and highly sensitive and selective mass spectrometric det ection systems to deliver the promise of HTPK. A historical perspective on automated bioanalysis with the current approaches and future prospects for the discipline are described.