Energy evaluation of MW effects on ACh receptor channels with parallel computing

Citation
F. Apollonio et al., Energy evaluation of MW effects on ACh receptor channels with parallel computing, ELEC MAGNET, 19(1), 2000, pp. 69-79
Citations number
32
Categorie Soggetti
Experimental Biology
Journal title
ELECTRO- AND MAGNETOBIOLOGY
ISSN journal
10619526 → ACNP
Volume
19
Issue
1
Year of publication
2000
Pages
69 - 79
Database
ISI
SICI code
1061-9526(2000)19:1<69:EEOMEO>2.0.ZU;2-Y
Abstract
We present an evaluation of the effects of microwave fields on the acetylch oline (ACh) receptor channel, based on energy issues. The channel is consid ered a stochastic automaton, flipping randomly from one state to another, a nd the incident field modifies transitions among the states. The observatio n of some appropriate biochemical parameters demonstrates that microwave fi elds cause conformational changes in the receptor site. An energetic mappin g of ACh conformational changes is also achieved, clearing the ground for f uture development of this research in the field of molecular simulations.